DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors

The tumor suppressor p53 promotes tumor-suppressive activities including cell-cycle inhibition, apoptosis, senescence, autophagy, and DNA repair. However, somatic mutations in the TP53 gene are one of the most common alterations in human cancers. We previously showed that mutant p53 (mutp53) can bin...

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Detalles Bibliográficos
Autores principales: Folly-Kossi, Helena, Graves, Joshua D., Garan, Lidija A. Wilhelms, Lin, Fang-Tsyr, Lin, Weei-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578204/
https://www.ncbi.nlm.nih.gov/pubmed/37756561
http://dx.doi.org/10.1158/2767-9764.CRC-23-0166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578204/
https://www.ncbi.nlm.nih.gov/pubmed/37756561
http://dx.doi.org/10.1158/2767-9764.CRC-23-0166

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