Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer’s Disease Mice

BACKGROUND: Alzheimer’s disease (AD) cases are often characterized by the pathological accumulation of α-synuclein (α-syn) in addition to amyloid-β (Aβ) and tau hallmarks. The role of α-syn has been extensively studied in synucleinopathy disorders, but less so in AD. Recent studies have shown that α...

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Detalles Bibliográficos
Autores principales: Leitão, André D.G., Spencer, Brian, Sarsoza, Floyd, Ngolab, Jennifer, Amalraj, Jessica, Masliah, Eliezer, Wu, Chengbiao, Rissman, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578232/
https://www.ncbi.nlm.nih.gov/pubmed/37522208
http://dx.doi.org/10.3233/JAD-230232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578232/
https://www.ncbi.nlm.nih.gov/pubmed/37522208
http://dx.doi.org/10.3233/JAD-230232

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