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Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects and Its relevance for Alzheimer’s Disease

BACKGROUND: Amyloid-β (Aβ) is a normal product of neuronal activity, including that of the aggregation-prone Aβ(42) variant that is thought to cause Alzheimer’s disease (AD). Much knowledge about AD comes from studies of transgenic rodents expressing mutated human amyloid-β protein precursor (AβPP)...

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Detalles Bibliográficos
Autores principales: Kobro-Flatmoen, Asgeir, Hormann, Thea Meier, Gouras, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578257/
https://www.ncbi.nlm.nih.gov/pubmed/37574734
http://dx.doi.org/10.3233/JAD-230349