DUX4 expression in cancer induces a metastable early embryonic totipotent program

The transcription factor DUX4 regulates a portion of the zygotic gene activation (ZGA) program in the early embryo. Many cancers express DUX4 but it is unknown whether this generates cells similar to early embryonic stem cells. Here we identified cancer cell lines that express DUX4 and showed that D...

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Detalles Bibliográficos
Autores principales: Smith, Andrew A., Nip, Yee, Bennett, Sean R., Hamm, Danielle C., Lemmers, Richard J.L.F., van der Vliet, Patrick J., Setty, Manu, van der Maarel, Silvère M., Tapscott, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578318/
https://www.ncbi.nlm.nih.gov/pubmed/37691147
http://dx.doi.org/10.1016/j.celrep.2023.113114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578318/
https://www.ncbi.nlm.nih.gov/pubmed/37691147
http://dx.doi.org/10.1016/j.celrep.2023.113114

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