Robust Strategy for Hit-to-Lead Discovery: NMR for SAR

[Image: see text] Establishing robust structure–activity relationships (SARs) is key to successful drug discovery campaigns, yet it often remains elusive due to screening and hit validation artifacts (false positives and false negatives), which frequently result in unproductive downstream expenditur...

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Detalles Bibliográficos
Autores principales: Larda, Sacha T., Ayotte, Yann, Denk, Maria M., Coote, Paul, Heffron, Gregory, Bendahan, David, Shahout, Fatma, Girard, Nicolas, Iddir, Mustapha, Bouchard, Patricia, Bilodeau, Francois, Woo, Simon, Farmer, Luc J., LaPlante, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578354/
https://www.ncbi.nlm.nih.gov/pubmed/37732695
http://dx.doi.org/10.1021/acs.jmedchem.3c00656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578354/
https://www.ncbi.nlm.nih.gov/pubmed/37732695
http://dx.doi.org/10.1021/acs.jmedchem.3c00656

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