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Discovering pathways through ribozyme fitness landscapes using information theoretic quantification of epistasis

The identification of catalytic RNAs is typically achieved through primarily experimental means. However, only a small fraction of sequence space can be analyzed even with high-throughput techniques. Methods to extrapolate from a limited data set to predict additional ribozyme sequences, particularl...

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Detalles Bibliográficos
Autores principales: Charest, Nathaniel, Shen, Yuning, Lai, Yei-Chen, Chen, Irene A., Shea, Joan-Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578471/
https://www.ncbi.nlm.nih.gov/pubmed/37580126
http://dx.doi.org/10.1261/rna.079541.122