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The DUF3715 domain has a conserved role in RNA-directed transposon silencing

RNA-directed transposon silencing operates in the mammalian soma and germline to safeguard genomic integrity. The piRNA pathway and the HUSH complex identify active transposons through recognition of their nascent transcripts, but mechanistic understanding of how these distinct pathways evolved is l...

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Detalles Bibliográficos
Autores principales: Schöpp, Theresa, Prigozhin, Daniil M., Douse, Christopher, Kaji, Keisuke, Cook, Atlanta G., O'Carroll, Dónal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578480/
https://www.ncbi.nlm.nih.gov/pubmed/37433650
http://dx.doi.org/10.1261/rna.079693.123