An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function. While the development of potent IP6K inhibitors is gaining momentum, a pharmacological tool to distinguish the mammali...

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Detalles Bibliográficos
Autores principales: Aguirre, Tim, Dornan, Gillian L, Hostachy, Sarah, Neuenschwander, Martin, Seyffarth, Carola, Haucke, Volker, Schütz, Anja, von Kries, Jens Peter, Fiedler, Dorothea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578927/
https://www.ncbi.nlm.nih.gov/pubmed/37843983
http://dx.doi.org/10.7554/eLife.88982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578927/
https://www.ncbi.nlm.nih.gov/pubmed/37843983
http://dx.doi.org/10.7554/eLife.88982

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