The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling

BACKGROUND: A significant level of CD70 can be detected in various types of tumor tissues and CD27 is expressed on Treg cells, but CD70 expression is low in normal tissues. The interaction between CD70 and CD27 can stimulate the proliferation and survival of cancer cells and increase the level of so...

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Detalles Bibliográficos
Autores principales: Li, Song, Chen, Dianze, Guo, Huiqin, Liu, Dandan, Yang, Chunmei, Zhang, Ruliang, Wang, Tianxiang, Zhang, Fan, Bai, Xing, Yang, Yanan, Sun, Nana, Zhang, Wei, Zhang, Li, Zhao, Gui, Peng, Liang, Tu, Xiaoping, Tian, Wenzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578964/
https://www.ncbi.nlm.nih.gov/pubmed/37849799
http://dx.doi.org/10.3389/fonc.2023.1240061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578964/
https://www.ncbi.nlm.nih.gov/pubmed/37849799
http://dx.doi.org/10.3389/fonc.2023.1240061

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