Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice

OBJECTIVES: Prior studies noted that chondrocyte SIRT6 activity is repressed in older chondrocytes rendering cells susceptible to catabolic signalling events implicated in osteoarthritis (OA). This study aimed to define the effect of Sirt6 deficiency on the development of post-traumatic and age-asso...

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Detalles Bibliográficos
Autores principales: Collins, John A, Kim, C James, Coleman, Ashley, Little, Abreah, Perez, Matheus M, Clarke, Emily J, Diekman, Brian, Peffers, Mandy J, Chubinskaya, Susanna, Tomlinson, Ryan E, Freeman, Theresa A, Loeser, Richard F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Osteoarthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579179/
https://www.ncbi.nlm.nih.gov/pubmed/37550003
http://dx.doi.org/10.1136/ard-2023-224385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579179/
https://www.ncbi.nlm.nih.gov/pubmed/37550003
http://dx.doi.org/10.1136/ard-2023-224385

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