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Screening of the antileishmanial and antiplasmodial potential of synthetic 2-arylquinoline analogs

In this study, six analogs of 2-arylquinoline were synthesized and evaluated for their in vitro and in vivo antiplasmodial and leishmanicidal activity. At a later stage, hemolytic activity and druggability were tested in vitro and in silico, respectively, observing as a result: firstly, compounds sh...

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Detalles Bibliográficos
Autores principales: Espinosa-Saez, Roger, Robledo, Sara M., Pineda, Tatiana, Murillo, Javier, Zúñiga, César, Yañez, Osvaldo, Cantero-López, Plinio, Saez-Vega, Alex, Guzmán-Teran, Camilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579228/
https://www.ncbi.nlm.nih.gov/pubmed/37845281
http://dx.doi.org/10.1038/s41598-023-43805-4