Core clock gene BMAL1 and RNA-binding protein MEX3A collaboratively regulate Lgr5 expression in intestinal crypt cells

The intestinal epithelium is highly regenerative. Rapidly proliferating LGR5(+) crypt base columnar (CBC) cells are responsible for epithelial turnover needed to maintain intestinal homeostasis. Upon tissue damage, loss of LGR5(+) CBCs can be compensated by activation of quiescent +4 intestinal stem...

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Detalles Bibliográficos
Autores principales: Cheng, Li-Tzu, Tan, Grace Y. T., Chang, Fang-Pei, Wang, Cheng-Kai, Chou, Yu-Chi, Hsu, Pang-Hung, Hwang-Verslues, Wendy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579233/
https://www.ncbi.nlm.nih.gov/pubmed/37845346
http://dx.doi.org/10.1038/s41598-023-44997-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579233/
https://www.ncbi.nlm.nih.gov/pubmed/37845346
http://dx.doi.org/10.1038/s41598-023-44997-5

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