Cargando…

Core clock gene BMAL1 and RNA-binding protein MEX3A collaboratively regulate Lgr5 expression in intestinal crypt cells

The intestinal epithelium is highly regenerative. Rapidly proliferating LGR5(+) crypt base columnar (CBC) cells are responsible for epithelial turnover needed to maintain intestinal homeostasis. Upon tissue damage, loss of LGR5(+) CBCs can be compensated by activation of quiescent +4 intestinal stem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Li-Tzu, Tan, Grace Y. T., Chang, Fang-Pei, Wang, Cheng-Kai, Chou, Yu-Chi, Hsu, Pang-Hung, Hwang-Verslues, Wendy W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579233/ https://www.ncbi.nlm.nih.gov/pubmed/37845346 http://dx.doi.org/10.1038/s41598-023-44997-5

Ejemplares similares

MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis
por: Wang, Cheng-Kai, et al.
Publicado: (2023)

Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML
por: Miki, Takao, et al.
Publicado: (2016)

MEX3A regulates Lgr5 (+) stem cell maintenance in the developing intestinal epithelium
por: Pereira, Bruno, et al.
Publicado: (2020)

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1
por: Shen, Yang, et al.
Publicado: (2021)

Regulation of circadian clock transcriptional output by CLOCK:BMAL1
por: Trott, Alexandra J., et al.
Publicado: (2018)

The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration
por: Stokes, Kyle, et al.
Publicado: (2017)

Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes
por: Marcheva, Biliana, et al.
Publicado: (2010)

PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells
por: Zagni, Chiara, et al.
Publicado: (2017)

Core clock gene Bmal1 deprivation impairs steroidogenesis in mice luteinized follicle cells
por: Wang, Yizi, et al.
Publicado: (2020)

Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease
por: Li, Lingling, et al.
Publicado: (2022)

BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance
por: Zhang, Canfeng, et al.
Publicado: (2023)

Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK
por: Langmesser, Sonja, et al.
Publicado: (2008)

The aging clock: to ‘BMAL'icious toward learning and memory
por: Gerstner, Jason R.
Publicado: (2010)

BMAL1 dephosphorylation determines the pace of the circadian clock
por: Schibler, Ueli
Publicado: (2021)

RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer
por: Zheng, Xulei, et al.
Publicado: (2019)

Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration
por: Wang, Dong, et al.
Publicado: (2022)

BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
por: Rudic, R. Daniel, et al.
Publicado: (2004)

CLOCK:BMAL1 is a pioneer-like transcription factor
por: Menet, Jerome S., et al.
Publicado: (2014)

Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1
por: Korkmaz, Tuba, et al.
Publicado: (2018)

The circadian clock component BMAL1 regulates osteogenesis in osseointegration
por: Deng, Shiyong, et al.
Publicado: (2022)

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1
por: Hu, Yan, et al.
Publicado: (2011)

Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity
por: Klemz, Sabrina, et al.
Publicado: (2021)

Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
por: Umemura, Yasuhiro, et al.
Publicado: (2021)

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number of LGR5+ Ectopic Stem Cells
por: Jennelle, Lucas T., et al.
Publicado: (2021)

Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXR [Formula: see text]-Regulated and CLOCK/BMAL1-Regulated Systems
por: Nakamura, Koh-ichi, et al.
Publicado: (2008)

Effects of BMAL1 Manipulation on the Brain’s Master Circadian Clock and Behavior
por: Haque, Samreen N., et al.
Publicado: (2019)

Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism
por: Wang, Xiao-Lan, et al.
Publicado: (2020)

Association of BMAL1 clock gene polymorphisms with fasting glucose in children
por: Yang, Yi-De, et al.
Publicado: (2023)

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock
por: Ye, Rui, et al.
Publicado: (2014)

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche
por: Langlands, Alistair J., et al.
Publicado: (2016)

The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas
por: Petrenko, Volodymyr, et al.
Publicado: (2020)

Core circadian clock transcription factor BMAL1 regulates mammary epithelial cell growth, differentiation, and milk component synthesis
por: Casey, Theresa, et al.
Publicado: (2021)

The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition
por: Yu, Fangjun, et al.
Publicado: (2019)

Nuclear envelope protein MAN1 regulates clock through BMAL1
por: Lin, Shu-Ting, et al.
Publicado: (2014)

BMAL1 LINKS THE CIRCADIAN CLOCK TO VIRAL AIRWAY PATHOLOGY AND ASTHMA PHENOTYPES
por: Ehlers, Anna, et al.
Publicado: (2017)

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
por: Lavtar, Polona, et al.
Publicado: (2018)

Deficiency of the clock gene Bmal1 affects neural progenitor cell migration
por: Ali, Amira A. H., et al.
Publicado: (2018)

Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines
por: Sakamoto, Akihiko, et al.
Publicado: (2021)

REGγ regulates circadian clock by modulating BMAL1 protein stability
por: Kubra, Syeda, et al.
Publicado: (2021)

Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism
por: Nakata, Masanori, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k2ah5gg4ohuut6mo61sj24gthh