Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive. Here, we identify that proline synthetase PYCR1 is critical for breast cancer stemness and tumor growth. Mechanistically, PYCR1-...

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Detalles Bibliográficos
Autores principales: Cui, Bai, He, Bin, Huang, Yanping, Wang, Cenxin, Luo, Huandong, Lu, Jinxin, Su, Keyu, Zhang, Xiaoyu, Luo, Yuanyuan, Zhao, Zhuoran, Yang, Yuqing, Zhang, Yunkun, An, Fan, Wang, Hong, Lam, Eric W.-F., Kelley, Keith W., Wang, Ling, Liu, Quentin, Peng, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579265/
https://www.ncbi.nlm.nih.gov/pubmed/37845207
http://dx.doi.org/10.1038/s41419-023-06200-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579265/
https://www.ncbi.nlm.nih.gov/pubmed/37845207
http://dx.doi.org/10.1038/s41419-023-06200-5

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