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TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling

Homeobox A5 (HOXA5), a homeodomain transcription factor, is considered a tumor suppressor in cancer progression; however, its function in prostate cancer (PCa) remains unclear. This study focused on the relevance of HOXA5 in PCa progression. We identified the downregulation of HOXA5 in PCa tissues b...

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Detalles Bibliográficos
Autores principales: Ye, Jianfeng, Liu, Wangmin, Yu, Xueyang, Wu, Lina, Chen, Zhengjie, Yu, Yufei, Wang, Jianfeng, Bai, Song, Zhang, Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579307/
https://www.ncbi.nlm.nih.gov/pubmed/37845209
http://dx.doi.org/10.1038/s41420-023-01675-9