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A critical re-evaluation of the slope factor of the operational model of agonism: When to exponentiate operational efficacy
Agonist efficacy denoting the “strength” of agonist action is a cornerstone in the proper assessment of agonist selectivity and signalling bias. The simulation models are very accurate but complex and hard to fit experimental data. The parsimonious operational model of agonism (OMA) has become succe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579308/ https://www.ncbi.nlm.nih.gov/pubmed/37845324 http://dx.doi.org/10.1038/s41598-023-45004-7 |