Expanding PROTACtable genome universe of E3 ligases

Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD) molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new opportunities to engage targets that remain challenging to be inhibited by conventional small molecules. One fundamental element in...

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Detalles Bibliográficos
Autores principales: Liu, Yuan, Yang, Jingwen, Wang, Tianlu, Luo, Mei, Chen, Yamei, Chen, Chengxuan, Ronai, Ze’ev, Zhou, Yubin, Ruppin, Eytan, Han, Leng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579327/
https://www.ncbi.nlm.nih.gov/pubmed/37845222
http://dx.doi.org/10.1038/s41467-023-42233-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579327/
https://www.ncbi.nlm.nih.gov/pubmed/37845222
http://dx.doi.org/10.1038/s41467-023-42233-2

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