Elexacaftor/VX-445–mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics

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Cystic fibrosis (CF) is one of the most prevalent lethal genetic diseases with over 2000 identified mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Pharmacological chaperones such as lumacaftor (VX-809), tezacaftor (VX-661), and elexacaftor (VX-445) treat mutation-i...

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Detalles Bibliográficos
Autores principales: Kim, Minsoo, McDonald, Eli Fritz, Sabusap, Carleen Mae P., Timalsina, Bibek, Joshi, Disha, Hong, Jeong S., Rab, Andras, Sorscher, Eric J., Plate, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579539/
https://www.ncbi.nlm.nih.gov/pubmed/37690692
http://dx.doi.org/10.1016/j.jbc.2023.105242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579539/
https://www.ncbi.nlm.nih.gov/pubmed/37690692
http://dx.doi.org/10.1016/j.jbc.2023.105242

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