The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model

Homeodomain-interacting protein kinases (Hipks) regulate cell proliferation, apoptosis, and tissue development. Overexpression of Hipk in Drosophila causes tumorigenic phenotypes in larval imaginal discs. We find that depletion of Salt-inducible kinases Sik2 or Sik3 can suppress Hipk-induced overgro...

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Detalles Bibliográficos
Autores principales: Yu, Kewei, Ramkumar, Niveditha, Wong, Kenneth Kin Lam, Tettweiler, Gritta, Verheyen, Esther M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579798/
https://www.ncbi.nlm.nih.gov/pubmed/37854071
http://dx.doi.org/10.3389/fcell.2023.1214539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579798/
https://www.ncbi.nlm.nih.gov/pubmed/37854071
http://dx.doi.org/10.3389/fcell.2023.1214539

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