Deucravacitinib, a tyrosine kinase 2 pseudokinase inhibitor, protects human EndoC-βH1 β-cells against proinflammatory insults

INTRODUCTION: Type 1 diabetes is characterized by pancreatic islet inflammation and autoimmune-driven pancreatic β-cell destruction. Interferon-α (IFNα) is a key player in early human type 1 diabetes pathogenesis. IFNα activates the tyrosine kinase 2 (TYK2)-signal transducer and activator of transcr...

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Detalles Bibliográficos
Autores principales: Dos Santos, Reinaldo S., Guzman-Llorens, Daniel, Perez-Serna, Atenea A., Nadal, Angel, Marroqui, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579912/
https://www.ncbi.nlm.nih.gov/pubmed/37854597
http://dx.doi.org/10.3389/fimmu.2023.1263926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579912/
https://www.ncbi.nlm.nih.gov/pubmed/37854597
http://dx.doi.org/10.3389/fimmu.2023.1263926

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