Serendipitous Discovery of T Cell–Produced KLK1b22 as a Regulator of Systemic Metabolism

In order to study mechanistic/mammalian target of rapamycin’s role in T cell differentiation, we generated mice in which Rheb is selectively deleted in T cells (T-Rheb(−/−) C57BL/6J background). During these studies, we noted that T-Rheb(−/−) mice were consistently heavier but had improved glucose t...

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Detalles Bibliográficos
Autores principales: Arwood, Matthew L., Sun, Im-Hong, Patel, Chirag H., Sun, Im-Meng, Oh, Min-Hee, Bettencourt, Ian A., Claiborne, Michael D., Chan-Li, Yee, Zhao, Liang, Waickman, Adam T., Mavrothalassitis, Orestes, Wen, Jiayu, Aja, Susan, Powell, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2023
Materias:
Adaptive Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580127/
https://www.ncbi.nlm.nih.gov/pubmed/37358498
http://dx.doi.org/10.4049/immunohorizons.2300016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580127/
https://www.ncbi.nlm.nih.gov/pubmed/37358498
http://dx.doi.org/10.4049/immunohorizons.2300016

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