Katdetectr: an R/bioconductor package utilizing unsupervised changepoint analysis for robust kataegis detection

BACKGROUND: Kataegis refers to the occurrence of regional genomic hypermutation in cancer and is a phenomenon that has been observed in a wide range of malignancies. A kataegis locus constitutes a genomic region with a high mutation rate (i.e., a higher frequency of closely interspersed somatic vari...

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Detalles Bibliográficos
Autores principales: Hazelaar, Daan M, van Riet, Job, Hoogstrate, Youri, van de Werken, Harmen J G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580377/
https://www.ncbi.nlm.nih.gov/pubmed/37848617
http://dx.doi.org/10.1093/gigascience/giad081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580377/
https://www.ncbi.nlm.nih.gov/pubmed/37848617
http://dx.doi.org/10.1093/gigascience/giad081

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