Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR

BACKGROUND: Breast cancer (BC) is the most common malignant disease in female patients worldwide. In HER-2+ BC patients, trastuzumab therapy is associated with a better prognosis. However, many HER-2+ BC patients experience recurrence or metastasis because of trastuzumab resistance. The mechanisms u...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Cuiwei, Lu, Chong, Yixi, Lamu, Hong, Jiaxing, Dong, Fang, Ruan, Shengnan, Hu, Ting, Zhao, Xiangwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580635/
https://www.ncbi.nlm.nih.gov/pubmed/37848981
http://dx.doi.org/10.1186/s13058-023-01720-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580635/
https://www.ncbi.nlm.nih.gov/pubmed/37848981
http://dx.doi.org/10.1186/s13058-023-01720-6

Ejemplares similares