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Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR

BACKGROUND: Breast cancer (BC) is the most common malignant disease in female patients worldwide. In HER-2+ BC patients, trastuzumab therapy is associated with a better prognosis. However, many HER-2+ BC patients experience recurrence or metastasis because of trastuzumab resistance. The mechanisms u...

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Detalles Bibliográficos
Autores principales:	Liu, Cuiwei, Lu, Chong, Yixi, Lamu, Hong, Jiaxing, Dong, Fang, Ruan, Shengnan, Hu, Ting, Zhao, Xiangwang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580635/ https://www.ncbi.nlm.nih.gov/pubmed/37848981 http://dx.doi.org/10.1186/s13058-023-01720-6

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