SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage

The recent emergence of the omicron variant of the SARS-CoV-2 virus with large numbers of mutations has raised concern about a potential new surge in infections. Here we use molecular dynamics to study the biophysics of the interface of the BA1 and BA2 omicron spike protein binding to (i) the ACE2 r...

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Detalles Bibliográficos
Autores principales: Jawaid, M. Zaki, Baidya, A., Mahboubi-Ardakani, R., Davis, Richard L., Cox, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580870/
https://www.ncbi.nlm.nih.gov/pubmed/37650619
http://dx.doi.org/10.1128/spectrum.01213-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580870/
https://www.ncbi.nlm.nih.gov/pubmed/37650619
http://dx.doi.org/10.1128/spectrum.01213-22

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