A novel in vitro system of supported planar endosomal membranes (SPEMs) reveals an enhancing role for cathepsin B in the final stage of Ebola virus fusion and entry

Ebola virus (EBOV) causes a hemorrhagic fever with fatality rates up to 90%. The EBOV entry process is complex and incompletely understood. Following attachment to host cells, EBOV is trafficked to late endosomes/lysosomes where its glycoprotein (GP) is processed to a 19-kDa form, which binds to the...

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Detalles Bibliográficos
Autores principales: Odongo, Laura, Habtegebrael, Betelihem H., Kiessling, Volker, White, Judith M., Tamm, Lukas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581071/
https://www.ncbi.nlm.nih.gov/pubmed/37728342
http://dx.doi.org/10.1128/spectrum.01908-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581071/
https://www.ncbi.nlm.nih.gov/pubmed/37728342
http://dx.doi.org/10.1128/spectrum.01908-23

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