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A novel in vitro system of supported planar endosomal membranes (SPEMs) reveals an enhancing role for cathepsin B in the final stage of Ebola virus fusion and entry
Ebola virus (EBOV) causes a hemorrhagic fever with fatality rates up to 90%. The EBOV entry process is complex and incompletely understood. Following attachment to host cells, EBOV is trafficked to late endosomes/lysosomes where its glycoprotein (GP) is processed to a 19-kDa form, which binds to the...
Autores principales: | Odongo, Laura, Habtegebrael, Betelihem H., Kiessling, Volker, White, Judith M., Tamm, Lukas K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581071/ https://www.ncbi.nlm.nih.gov/pubmed/37728342 http://dx.doi.org/10.1128/spectrum.01908-23 |
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