Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice

Sezary syndrome (SS) is a rare, aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) that lacks adequate therapeutic options and representative small-animal models. Here, we demonstrate that IL-15 is a critical CTCL growth factor. Importantly, an immunodeficient knock-in mouse model genet...

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Detalles Bibliográficos
Autores principales: Gao, Jie, Ren, Shumei, Choonoo, Gabrielle, Chen, Guoying, Frleta, Davor, Zhong, Jun, Gupta, Namita, Sharma, Prachi, Oyejide, Adelekan, Atwal, Gurinder S., Macdonald, Lynn, Murphy, Andrew, Kuhnert, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581384/
https://www.ncbi.nlm.nih.gov/pubmed/37718909
http://dx.doi.org/10.1242/dmm.050190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581384/
https://www.ncbi.nlm.nih.gov/pubmed/37718909
http://dx.doi.org/10.1242/dmm.050190

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