A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities

p53 (encoded by Trp53) is a tumor suppressor, but mouse models have revealed that increased p53 activity may cause bone marrow failure, likely through dimerization partner, RB-like, E2F4/E2F5 and MuvB (DREAM) complex-mediated gene repression. Here, we designed a systematic approach to identify p53-D...

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Detalles Bibliográficos
Autores principales: Rakotopare, Jeanne, Lejour, Vincent, Duval, Carla, Eldawra, Eliana, Escoffier, Hugues, Toledo, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581385/
https://www.ncbi.nlm.nih.gov/pubmed/37661832
http://dx.doi.org/10.1242/dmm.050376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581385/
https://www.ncbi.nlm.nih.gov/pubmed/37661832
http://dx.doi.org/10.1242/dmm.050376

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