Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency

Cardiomyopathy is often fatal in Friedreich ataxia (FA). However, FA hearts maintain adequate function until advanced disease stages, suggesting initial adaptation to the loss of frataxin (FXN). Conditional cardiac knockout mouse models of FXN show transcriptional and metabolic profiles of the mitoc...

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Detalles Bibliográficos
Autores principales: Sayles, Nicole M., Napierala, Jill S., Anrather, Josef, Diedhiou, Nadège, Li, Jixue, Napierala, Marek, Puccio, Hélène, Manfredi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581388/
https://www.ncbi.nlm.nih.gov/pubmed/37691621
http://dx.doi.org/10.1242/dmm.050114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581388/
https://www.ncbi.nlm.nih.gov/pubmed/37691621
http://dx.doi.org/10.1242/dmm.050114

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