Predicting CRISPR-Cas12a guide efficiency for targeting using machine learning

Genome editing through the development of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)–Cas technology has revolutionized many fields in biology. Beyond Cas9 nucleases, Cas12a (formerly Cpf1) has emerged as a promising alternative to Cas9 for editing AT-rich genomes. Despite the...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Brien, Aidan, Bauer, Denis C., Burgio, Gaetan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581463/
https://www.ncbi.nlm.nih.gov/pubmed/37847697
http://dx.doi.org/10.1371/journal.pone.0292924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581463/
https://www.ncbi.nlm.nih.gov/pubmed/37847697
http://dx.doi.org/10.1371/journal.pone.0292924

Ejemplares similares