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Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more seri...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581570/ https://www.ncbi.nlm.nih.gov/pubmed/37721285 http://dx.doi.org/10.4103/1673-5374.380871 |
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author | Han, Bo Liang, Weishi Hai, Yong Sun, Duan Ding, Hongtao Yang, Yihan Yin, Peng |
author_facet | Han, Bo Liang, Weishi Hai, Yong Sun, Duan Ding, Hongtao Yang, Yihan Yin, Peng |
author_sort | Han, Bo |
collection | PubMed |
description | Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more serious in terms of their neurophysiology, histology, and behavior. Very few studies have been published on the specific characteristics of distraction spinal cord injury. In this study, we systematically review 22 related studies involving animal models of distraction spinal cord injury, focusing particularly on the neurophysiological, histological, and behavioral characteristics of this disease. In addition, we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury. We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research, and provide reference guidelines for the clinical diagnosis and treatment of this disease. |
format | Online Article Text |
id | pubmed-10581570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-105815702023-10-18 Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review Han, Bo Liang, Weishi Hai, Yong Sun, Duan Ding, Hongtao Yang, Yihan Yin, Peng Neural Regen Res Review Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more serious in terms of their neurophysiology, histology, and behavior. Very few studies have been published on the specific characteristics of distraction spinal cord injury. In this study, we systematically review 22 related studies involving animal models of distraction spinal cord injury, focusing particularly on the neurophysiological, histological, and behavioral characteristics of this disease. In addition, we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury. We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research, and provide reference guidelines for the clinical diagnosis and treatment of this disease. Wolters Kluwer - Medknow 2023-07-20 /pmc/articles/PMC10581570/ /pubmed/37721285 http://dx.doi.org/10.4103/1673-5374.380871 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Han, Bo Liang, Weishi Hai, Yong Sun, Duan Ding, Hongtao Yang, Yihan Yin, Peng Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review |
title | Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review |
title_full | Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review |
title_fullStr | Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review |
title_full_unstemmed | Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review |
title_short | Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review |
title_sort | neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581570/ https://www.ncbi.nlm.nih.gov/pubmed/37721285 http://dx.doi.org/10.4103/1673-5374.380871 |
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