Cargando…

Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review

Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more seri...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Bo, Liang, Weishi, Hai, Yong, Sun, Duan, Ding, Hongtao, Yang, Yihan, Yin, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581570/
https://www.ncbi.nlm.nih.gov/pubmed/37721285
http://dx.doi.org/10.4103/1673-5374.380871
_version_ 1785122165818916864
author Han, Bo
Liang, Weishi
Hai, Yong
Sun, Duan
Ding, Hongtao
Yang, Yihan
Yin, Peng
author_facet Han, Bo
Liang, Weishi
Hai, Yong
Sun, Duan
Ding, Hongtao
Yang, Yihan
Yin, Peng
author_sort Han, Bo
collection PubMed
description Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more serious in terms of their neurophysiology, histology, and behavior. Very few studies have been published on the specific characteristics of distraction spinal cord injury. In this study, we systematically review 22 related studies involving animal models of distraction spinal cord injury, focusing particularly on the neurophysiological, histological, and behavioral characteristics of this disease. In addition, we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury. We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research, and provide reference guidelines for the clinical diagnosis and treatment of this disease.
format Online
Article
Text
id pubmed-10581570
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-105815702023-10-18 Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review Han, Bo Liang, Weishi Hai, Yong Sun, Duan Ding, Hongtao Yang, Yihan Yin, Peng Neural Regen Res Review Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more serious in terms of their neurophysiology, histology, and behavior. Very few studies have been published on the specific characteristics of distraction spinal cord injury. In this study, we systematically review 22 related studies involving animal models of distraction spinal cord injury, focusing particularly on the neurophysiological, histological, and behavioral characteristics of this disease. In addition, we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury. We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research, and provide reference guidelines for the clinical diagnosis and treatment of this disease. Wolters Kluwer - Medknow 2023-07-20 /pmc/articles/PMC10581570/ /pubmed/37721285 http://dx.doi.org/10.4103/1673-5374.380871 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Han, Bo
Liang, Weishi
Hai, Yong
Sun, Duan
Ding, Hongtao
Yang, Yihan
Yin, Peng
Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
title Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
title_full Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
title_fullStr Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
title_full_unstemmed Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
title_short Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
title_sort neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581570/
https://www.ncbi.nlm.nih.gov/pubmed/37721285
http://dx.doi.org/10.4103/1673-5374.380871
work_keys_str_mv AT hanbo neurophysiologicalhistologicalandbehavioralcharacterizationofanimalmodelsofdistractionspinalcordinjuryasystematicreview
AT liangweishi neurophysiologicalhistologicalandbehavioralcharacterizationofanimalmodelsofdistractionspinalcordinjuryasystematicreview
AT haiyong neurophysiologicalhistologicalandbehavioralcharacterizationofanimalmodelsofdistractionspinalcordinjuryasystematicreview
AT sunduan neurophysiologicalhistologicalandbehavioralcharacterizationofanimalmodelsofdistractionspinalcordinjuryasystematicreview
AT dinghongtao neurophysiologicalhistologicalandbehavioralcharacterizationofanimalmodelsofdistractionspinalcordinjuryasystematicreview
AT yangyihan neurophysiologicalhistologicalandbehavioralcharacterizationofanimalmodelsofdistractionspinalcordinjuryasystematicreview
AT yinpeng neurophysiologicalhistologicalandbehavioralcharacterizationofanimalmodelsofdistractionspinalcordinjuryasystematicreview