Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of Pten knockout or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allowing them to regenerate axons in the injured optic n...

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Detalles Bibliográficos
Autores principales: Leibinger, Marco, Zeitler, Charlotte, Paulat, Miriam, Gobrecht, Philipp, Hilla, Alexander, Andreadaki, Anastasia, Guthoff, Rainer, Fischer, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581688/
https://www.ncbi.nlm.nih.gov/pubmed/37846146
http://dx.doi.org/10.7554/eLife.88279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581688/
https://www.ncbi.nlm.nih.gov/pubmed/37846146
http://dx.doi.org/10.7554/eLife.88279

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