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Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants

Cardenolides are specialized, steroidal metabolites produced in a wide array of plant families(1,2). Cardenolides play protective roles in plants, but these molecules, including digoxin from foxglove (Digitalis spp.), are better known for treatment of congenital heart failure, atrial arrhythmia, var...

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Detalles Bibliográficos
Autores principales: Kunert, Maritta, Langley, Chloe, Lucier, Rosalind, Ploss, Kerstin, Rodríguez López, Carlos E., Serna Guerrero, Delia A., Rothe, Eva, O’Connor, Sarah E., Sonawane, Prashant D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581899/
https://www.ncbi.nlm.nih.gov/pubmed/37723202
http://dx.doi.org/10.1038/s41477-023-01515-9