An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear. Here we show that c-terminal Tyr 530 is a de facto c-Src autophosphorylation site wi...

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Detalles Bibliográficos
Autores principales: Cuesta-Hernández, Hipólito Nicolás, Contreras, Julia, Soriano-Maldonado, Pablo, Sánchez-Wandelmer, Jana, Yeung, Wayland, Martín-Hurtado, Ana, Muñoz, Inés G., Kannan, Natarajan, Llimargas, Marta, Muñoz, Javier, Plaza-Menacho, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582172/
https://www.ncbi.nlm.nih.gov/pubmed/37848415
http://dx.doi.org/10.1038/s41467-023-41890-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582172/
https://www.ncbi.nlm.nih.gov/pubmed/37848415
http://dx.doi.org/10.1038/s41467-023-41890-7

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