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An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function
Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear. Here we show that c-terminal Tyr 530 is a de facto c-Src autophosphorylation site wi...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582172/ https://www.ncbi.nlm.nih.gov/pubmed/37848415 http://dx.doi.org/10.1038/s41467-023-41890-7 |