Enantioselective S(N)2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis (Adv. Sci. 29/2023)

Enantioselective β‐Alkylation In article number 2303517, Yong Huang, Jiean Chen, and co‐workers, describe a novel S(N)2 reaction mode for NHC‐mediated homoenolate chemistry, enabling enantioselective β‐alkylation, allylation and propargylation of enals. By combining with a “transient acyl trap” stra...

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Detalles Bibliográficos
Autores principales: Li, En, Tang, Kai, Ren, Zhuhui, Liao, Xiaoyun, Liu, Qianchen, Huang, Yong, Chen, Jiean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582437/
http://dx.doi.org/10.1002/advs.202370196
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author Li, En
Tang, Kai
Ren, Zhuhui
Liao, Xiaoyun
Liu, Qianchen
Huang, Yong
Chen, Jiean
author_facet Li, En
Tang, Kai
Ren, Zhuhui
Liao, Xiaoyun
Liu, Qianchen
Huang, Yong
Chen, Jiean
author_sort Li, En
collection PubMed
description Enantioselective β‐Alkylation In article number 2303517, Yong Huang, Jiean Chen, and co‐workers, describe a novel S(N)2 reaction mode for NHC‐mediated homoenolate chemistry, enabling enantioselective β‐alkylation, allylation and propargylation of enals. By combining with a “transient acyl trap” strategy, a diverse collection of chiral oxindole derivatives could be accessed, offering an efficient synthetic entry to the pyrroloindoline motif frequently encountered in natural products. [Image: see text]
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spelling pubmed-105824372023-10-19 Enantioselective S(N)2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis (Adv. Sci. 29/2023) Li, En Tang, Kai Ren, Zhuhui Liao, Xiaoyun Liu, Qianchen Huang, Yong Chen, Jiean Adv Sci (Weinh) Inside Front Cover Enantioselective β‐Alkylation In article number 2303517, Yong Huang, Jiean Chen, and co‐workers, describe a novel S(N)2 reaction mode for NHC‐mediated homoenolate chemistry, enabling enantioselective β‐alkylation, allylation and propargylation of enals. By combining with a “transient acyl trap” strategy, a diverse collection of chiral oxindole derivatives could be accessed, offering an efficient synthetic entry to the pyrroloindoline motif frequently encountered in natural products. [Image: see text] John Wiley and Sons Inc. 2023-10-17 /pmc/articles/PMC10582437/ http://dx.doi.org/10.1002/advs.202370196 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Inside Front Cover
Li, En
Tang, Kai
Ren, Zhuhui
Liao, Xiaoyun
Liu, Qianchen
Huang, Yong
Chen, Jiean
Enantioselective S(N)2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis (Adv. Sci. 29/2023)
title Enantioselective S(N)2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis (Adv. Sci. 29/2023)
title_full Enantioselective S(N)2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis (Adv. Sci. 29/2023)
title_fullStr Enantioselective S(N)2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis (Adv. Sci. 29/2023)
title_full_unstemmed Enantioselective S(N)2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis (Adv. Sci. 29/2023)
title_short Enantioselective S(N)2 Alkylation of Homoenolates by N‐Heterocyclic Carbene Catalysis (Adv. Sci. 29/2023)
title_sort enantioselective s(n)2 alkylation of homoenolates by n‐heterocyclic carbene catalysis (adv. sci. 29/2023)
topic Inside Front Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582437/
http://dx.doi.org/10.1002/advs.202370196
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