Self‐Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice

In tauopathy conditions, such as Alzheimer's disease (AD), highly soluble and natively unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this process remain unclear. In the brains of AD patients, only a minor segment of tau forms β‐helix‐stacked protofilam...

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Detalles Bibliográficos
Autores principales: Le, Ly Thi Huong Luu, Lee, Jeeyoung, Im, Dongjoon, Park, Sunha, Hwang, Kyoung‐Doo, Lee, Jung Hoon, Jiang, Yanxialei, Lee, Yong‐Seok, Suh, Young Ho, Kim, Hugh I., Lee, Min Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582461/
https://www.ncbi.nlm.nih.gov/pubmed/37594721
http://dx.doi.org/10.1002/advs.202302035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582461/
https://www.ncbi.nlm.nih.gov/pubmed/37594721
http://dx.doi.org/10.1002/advs.202302035

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