Addition of exogenous diacylglycerol enhances Wnt/β-catenin signaling through stimulation of macropinocytosis

Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now report that the exogenous addition of the second messenger lipid sn-1,2 DAG to the culture medium rapidly induces macropinocytosis. This is accompanied by potentiation of the effects of added Wnt3a recombinant prote...

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Detalles Bibliográficos
Autores principales: Azbazdar, Yagmur, Tejeda-Munoz, Nydia, Monka, Julia C., Dayrit, Alex, Binder, Grace, Ozhan, Gunes, De Robertis, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582480/
https://www.ncbi.nlm.nih.gov/pubmed/37860772
http://dx.doi.org/10.1016/j.isci.2023.108075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582480/
https://www.ncbi.nlm.nih.gov/pubmed/37860772
http://dx.doi.org/10.1016/j.isci.2023.108075

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