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Addition of exogenous diacylglycerol enhances Wnt/β-catenin signaling through stimulation of macropinocytosis
Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now report that the exogenous addition of the second messenger lipid sn-1,2 DAG to the culture medium rapidly induces macropinocytosis. This is accompanied by potentiation of the effects of added Wnt3a recombinant prote...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582480/ https://www.ncbi.nlm.nih.gov/pubmed/37860772 http://dx.doi.org/10.1016/j.isci.2023.108075 |