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An interpretable machine learning pipeline based on transcriptomics predicts phenotypes of lupus patients

Machine learning (ML) has the potential to identify subsets of patients with distinct phenotypes from gene expression data. However, phenotype prediction using ML has often relied on identifying important genes without a systems biology context. To address this, we created an interpretable ML approa...

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Detalles Bibliográficos
Autores principales: Leventhal, Emily L., Daamen, Andrea R., Grammer, Amrie C., Lipsky, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582499/
https://www.ncbi.nlm.nih.gov/pubmed/37860757
http://dx.doi.org/10.1016/j.isci.2023.108042