Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study

Spirochromanes incorporating Schiff's bases and semicarbazones 4a-e and 5a-j were synthesizedand analyzed for their potential antiproliferative activity using four human cancer cell lines (MCF-7, HCT-116, PC3, and A549). Compounds 5a, 5b and 5g possessed the highest antiproliferative activity a...

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Detalles Bibliográficos
Autores principales: Othman, Dina I.A., Hamdi, Abdelrahman, Elhusseiny, Walaa M., El-Azab, Adel S., Bakheit, Ahmed H., Hefnawy, Mohamed, Abdel-Aziz, Alaa A.-M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582582/
https://www.ncbi.nlm.nih.gov/pubmed/37860686
http://dx.doi.org/10.1016/j.jsps.2023.101803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582582/
https://www.ncbi.nlm.nih.gov/pubmed/37860686
http://dx.doi.org/10.1016/j.jsps.2023.101803

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