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Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study
Spirochromanes incorporating Schiff's bases and semicarbazones 4a-e and 5a-j were synthesizedand analyzed for their potential antiproliferative activity using four human cancer cell lines (MCF-7, HCT-116, PC3, and A549). Compounds 5a, 5b and 5g possessed the highest antiproliferative activity a...
Autores principales: | Othman, Dina I.A., Hamdi, Abdelrahman, Elhusseiny, Walaa M., El-Azab, Adel S., Bakheit, Ahmed H., Hefnawy, Mohamed, Abdel-Aziz, Alaa A.-M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582582/ https://www.ncbi.nlm.nih.gov/pubmed/37860686 http://dx.doi.org/10.1016/j.jsps.2023.101803 |
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