Co‐consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants

Green tea is a popular beverage worldwide. The abundant green tea catechin (−)‐epigallocatechin gallate (EGCG) is a potent in vitro inhibitor of intestinal UDP‐glucuronosyltransferase (UGT) activity (K ( i ) ~2 μM). Co‐consuming green tea with intestinal UGT drug substrates, including raloxifene, co...

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Detalles Bibliográficos
Autores principales: Clarke, John D., Judson, Sabrina M., Tian, Dan‐Dan, Kirby, Trevor O., Tanna, Rakshit S., Matula‐Péntek, Adrienn, Horváth, Miklós, Layton, Matthew E., White, John R., Cech, Nadja B., Thummel, Kenneth E., McCune, Jeannine S., Shen, Danny D., Paine, Mary F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582660/
https://www.ncbi.nlm.nih.gov/pubmed/37639334
http://dx.doi.org/10.1111/cts.13578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582660/
https://www.ncbi.nlm.nih.gov/pubmed/37639334
http://dx.doi.org/10.1111/cts.13578

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