Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients

Tacrolimus, the most common immunosuppressant for organ transplant, has a narrow therapeutic range and is metabolized by CYP3A4/5. Trough concentration monitoring and dosing adjustments are used to reach a therapeutic range. CYP3A5 intermediate and normal metabolizers (*1 allele carriers; IM/NM) dem...

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Detalles Bibliográficos
Autores principales: Alghamdi, Alaa, Seay, Sarah, Hooper, David K., Varnell, Charles D., Darland, Leanna, Mizuno, Tomoyuki, Lazear, Danielle, Ramsey, Laura B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582663/
https://www.ncbi.nlm.nih.gov/pubmed/37340713
http://dx.doi.org/10.1111/cts.13571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582663/
https://www.ncbi.nlm.nih.gov/pubmed/37340713
http://dx.doi.org/10.1111/cts.13571

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