Pharmacokinetics, safety, and tolerability of BMS‐986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment

BMS‐986263 is a retinoid‐conjugated lipid nanoparticle delivering small interfering RNA designed to inhibit synthesis of HSP47 protein, a collagen‐specific chaperone protein involved in fibrosis development. This is a phase I, open‐label, two‐part study evaluating pharmacokinetics and safety of BMS‐...

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Detalles Bibliográficos
Autores principales: Qosa, Hisham, de Oliveira, Claudia H. M. C., Cizza, Giovanni, Lawitz, Eric J., Colletti, Nicholas, Wetherington, Jeffrey, Charles, Edgar D., Tirucherai, Giridhar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582666/
https://www.ncbi.nlm.nih.gov/pubmed/37654022
http://dx.doi.org/10.1111/cts.13581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582666/
https://www.ncbi.nlm.nih.gov/pubmed/37654022
http://dx.doi.org/10.1111/cts.13581

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