Energy status regulates levels of the RAR/RXR ligand 9-cis-retinoic acid in mammalian tissues: Glucose reduces its synthesis in β-cells

9-cis-retinoic acid (9cRA) binds retinoic acid receptors (RAR) and retinoid X receptors (RXR) with nanomolar affinities, in contrast to all-trans-retinoic acid (atRA), which binds only RAR with nanomolar affinities. RXR heterodimerize with type II nuclear receptors, including RAR, to regulate a vast...

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Detalles Bibliográficos
Autores principales: Yoo, Hong Sik, Moss, Kristin Obrochta, Cockrum, Michael A., Woo, Wonsik, Napoli, Joseph L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582780/
https://www.ncbi.nlm.nih.gov/pubmed/37714463
http://dx.doi.org/10.1016/j.jbc.2023.105255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582780/
https://www.ncbi.nlm.nih.gov/pubmed/37714463
http://dx.doi.org/10.1016/j.jbc.2023.105255

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