B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus

OBJECTIVE: B cell function and autoantibodies are important in SLE pathogenesis. In this work, we aimed to investigate the impact of cumulative SLE B cell genetics on SLE subphenotype and autoantibody profile. METHODS: Female patients with SLE (n=1248) and healthy controls (n=400) were genotyped usi...

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Detalles Bibliográficos
Autores principales: Hedenstedt, Anna, Reid, Sarah, Sayadi, Ahmed, Eloranta, Maija-Leena, Skoglund, Elisabeth, Bolin, Karin, Frodlund, Martina, Lerang, Karoline, Jönsen, Andreas, Rantapää-Dahlqvist, Solbritt, Bengtsson, Anders A, Rudin, Anna, Molberg, Øyvind, Sjöwall, Christopher, Sandling, Johanna K, Leonard, Dag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582984/
https://www.ncbi.nlm.nih.gov/pubmed/37844960
http://dx.doi.org/10.1136/lupus-2023-000926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582984/
https://www.ncbi.nlm.nih.gov/pubmed/37844960
http://dx.doi.org/10.1136/lupus-2023-000926

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