Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B

The orally available anti‐hepatitis C virus (HCV) drug simeprevir exhibits nonlinear pharmacokinetics at the clinical doses due to saturation of cytochrome P450 (CYP) 3A4 metabolism and organic anion transporting peptide (OATP) 1B mediated hepatic uptake. Additionally, simeprevir increases exposures...

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Detalles Bibliográficos
Autores principales: Nakayama, Shinji, Toshimoto, Kota, Yamazaki, Shinji, Snoeys, Jan, Sugiyama, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583237/
https://www.ncbi.nlm.nih.gov/pubmed/37667529
http://dx.doi.org/10.1002/psp4.13023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583237/
https://www.ncbi.nlm.nih.gov/pubmed/37667529
http://dx.doi.org/10.1002/psp4.13023

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