Pathogenic signal peptide variants in the human genome

Secreted and membrane proteins represent a third of all cellular proteins and contain N-terminal signal peptides that are required for protein targeting to endoplasmic reticulum (ER). Mutations in signal peptides affect protein targeting, translocation, processing, and stability, and are associated...

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Detalles Bibliográficos
Autores principales: Gutierrez Guarnizo, Sneider Alexander, Kellogg, Morgana K, Miller, Sarah C, Tikhonova, Elena B, Karamysheva, Zemfira N, Karamyshev, Andrey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Standard Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583284/
https://www.ncbi.nlm.nih.gov/pubmed/37859801
http://dx.doi.org/10.1093/nargab/lqad093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583284/
https://www.ncbi.nlm.nih.gov/pubmed/37859801
http://dx.doi.org/10.1093/nargab/lqad093

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